Protein Purification
MilliporeSigma™ Calbiochem™ PERK Inhibitor I, GSK2606414
GSK2606414 is a cell-permeable, highly potent inhibitor of EIF2AK3/PERK (IC50 = 0.4 nM; [ATP] = 5 μM). Targets PERK in its inactive DFG conformation at the ATP-binding region.
MilliporeSigma™ Calbiochem™ AICA-Riboside
AICA-Riboside, CAS 2627-69-2, is a cell-permeable nucleoside compound whose phosphorylated metabolite activates AMPK and acts as a regulator of de novo purine synthesis.
MilliporeSigma™ Calbiochem™ InSolution™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor
The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for Phosphorylation & Dephosphorylation apps.
MilliporeSigma™ Calbiochem™ TrpA1 Antagonist, HC-030031
The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ Gβγ Modulator II, Gallein
A cell-permeable xanthene compound that binds to Gβγ with high affinity (K
MilliporeSigma™ Calbiochem™ Bisindolylmaleimide I
A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine.
MilliporeSigma™ Calbiochem™ TRPV4 Agonist, GSK1016790A
A cell-permeable, potent, selective agonist of TRPV4 channel. Enhances Ca2+ flux in a variety of human and mouse cells (EC50 = 2.1 nM for human TRPV4).
MilliporeSigma™ Calbiochem™ ALDH3A1 Inhibitor, CB29
A cell permeable, selective, reversible, substrate-binding site directed inhibitor of aldehyde dehydrogenase ALDH3A1 (Ki = 4.7 μM, IC50 = 16 μM).
MilliporeSigma™ Calbiochem™ Quercetin, Dihydrate
A cell-permeable and reversible inhibitor of PIM1 kinase (IC50 = 43nM), PI 3-K (IC50 = 3.8μM) and phospholipase A2
MilliporeSigma™ Calbiochem™ W-7, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM).
MilliporeSigma™ Calbiochem™ Cathepsin K Inhibitor II
The Cathepsin K Inhibitor II controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Cisplatin
Reported to sensitize glioma cells to TNF-α-induced apoptosis.
MilliporeSigma™ Calbiochem™ ICI 118551 Hydrochloride
A highly selective antagonist for the β2 adrenergic receptors
MilliporeSigma™ Calbiochem™ Gö 6976
Gö 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC50 = 7.9 nM for rat brain). Exhibits selectively for PKCα (IC50 = 2.3 nM) and βI (IC50 = 6.2 nM).
MilliporeSigma™ Calbiochem™ VEGFR Tyrosine Kinase Inhibitor VI, AAL-993
The VEGFR Tyrosine Kinse Inhibitor VI, ALL-993, also referenced under CAS 269390-77-4, controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Cancer applications.